Effect of laser irradiation on the progression of skin cancer using carcinogen among hamsters

Document Type : Original Paper

Authors

1 Medical Physics, postgraduate student (PhD) of Higher Institute for Laser Research and Applications, Damascus University, Damascus, Syria.

2 Prof. Dr. Nabil Kochaji DDS, MSc, PhD, Oral Pathologist Dean of Faculty of Dentistry, Al-Sham University. Department of Oral Pathology, Damascus University

3 2- Biomedical Photonics laboratory, Higher Institute for Laser Research and Applications- Damascus University-Syria

Abstract

Introduction: Skin cancer has been increased day by day, but it can be cured if it diagnosed early. After reviewing the scientific literature about 980 nm diode laser, and its multiple advantages on skin diseases. We studied in this paper the effectiveness of this type of laser on the progression of skin cancer among hamsters which were exposed to carcinogen on the back.
Material and Methods: The carcinogenic solution of 9, 10-dime thy 1-1, 2-benzanthracene was applied to the hamsters' skin on the back. A 980 nm Diode laser light with irradiation power of 0.5w and 1.0w and an exposure time of 100 sec were used in order to prevent the harmful thermal effect on surrounding tissue as studied in previous paper [1].
Results: According to the results, only one group of hamsters which was not consistently irradiated by laser gave rise to melanoma tumor. The other groups that were exposed to diode 980nm laser irradiation at different powers (i.e., 0.5w and 1.0w) and an exposure time of 100 sec showed no growth of skin cancer during the experiment.
Conclusion: The 980 nm Diode laser has an effect on delaying the onset of cancer and has had a role in the reduction of skin cancer lesions. However, further studies are required to test its inhibitory activities against carcinogenesis. 

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References

  1. References

     

    1. Kawthar Shurrab, Nabil Kochaji, Wesam Bachir,”Development of Temperature Distribution and Light Propagation Model in Biological Tissue Irradiated by 980 nm Laser Diode and Using COMSOL Simulation”, Journal of Laser in Medical Science, Vol 8, No 3(2017).
    2. Takashi Sugimura, “Studies on environmental chemical carcinogenesis in Japan”, Science, vol. 233, 1986, p. 312+. Academic OneFile.
    3. PhillippesHubik, HilippesHubik, Giuseppe Pietra, AndgiuseppedellAporta, “Studies of Skin Carcinogenesis in the Syrian Golden Hamster”, July 20,1995
    4. Chen W.R.; Richey J.W.; Bartles K.E; Liu H. and Nordddquist R.E. (2002),”Effect of Different Components of Laser Immunotherapy In Treatment of Metasstatic Tumors In Rats”. Cancer Res 62:4295-4299.
    5. Chong LP , Ozler SA , de Queiroz JM Jr , Liggett PE, “Indocyanine green-enhanced diode laser treatment of melanoma in a rabbit model”, Europe PMC, Jan 1993, 13(3):251-259.
    6. HARRYS. N. GREENE, “ A Spontaneous Melanoma in the Hamster with a Propensity for Amelanotic Alteration and SarcomatousTransformation during Transplantation”, American Association for Cancer Research, 1958, Vol. 18, May.
    7. C.S. Souza MD, PhDa,∗, L.B.A. Felicio a, J. Ferreirab, C. Kurachib,M.V.B. Bentleyc, A.C. Tedescod, V.S. Bagnatob”Long-term follow-up of topical 5-aminolaevulinicacid photodynamic therapy diode laser singlesession for non-melanoma skin cancer” Photodiagnosis and Photodynamic Therapy (2009) 6, 207—213.
    8. Cynthia S.Cook, David A. Wilkie, “Treatment of presumed iris melanoma in dogs by diode laser photocoagulation: 23 cases”, Veterinary Ophthalmology, Volume 2, Issue 4 December 1999, Pages 217–225.
    9. Marmur ES, Schmults CD, Goldberg DJ.” A Review Of Laser And Photodynamic Therapy For The Treatment Of Nonmelanoma Skin Cancer. Dermatol Surg” 2004, 30(2 Pt 2):264—71.
    10. Ekaterina I. Galanzha, Evgeny V. Shashkov, Paul M. Spring, James Y. Suen and Vladimir P. Zharov, “In vivo, Noninvasive, Label-Free Detection and Eradication of Circulating Metastatic Melanoma Cells Using Two-Color Photoacoustic Flow Cytometry with a Diode Laser” American Association for Cancer Research. 2009, Volume 69, Issue 20
    11. Apollonia DESIATE, Stefania CANTORE, Domenica TULLO, Giovanni PROFETA, Felice Roberto GRASSI, andAndrea BALLINI,” 980 nm diode lasers in oral and facial practice: current state of the science and art”, international journal of medical science.
    12. Huaxu Liu MD, PhD, Yongyan Dang PhD, Zhan Wang MD, PhD, Xinyu Chai PhD, Qiushi Ren PhD, “Laser induced collagen remodeling: A comparative study in vivo on mouse model”, Lasers In Surgery And Medicine, Volume 40, Issue 1January 2008 Pages 13–19.
    13. Romanos GE, Henze M, Banihashemi S, Parsanejad HR, Winckler J, Nentwig GH. Removal of epithelium in periodontal pockets following diode (980 nm) laser application in the animal model: an in vitro study. Photomed Laser Surg. 2004 Jun; 22(3):177–83. [PubMed].
    14. Richard Rox Anderson, “Lasers in Dermatology—A Critical Update
    15. Authors” The journal of dermatology, November 2000, Volume 27, Issue 11, Pages 700–705.
    16. Clare Horkan, BCh Kshitij Dalal, Jeffrey A. Coderre,” Reduced Tumor Growth with Combined Radiofrequency Ablation and Radiation Therapy in a Rat Breast Tumor Model”, 2005; 235:81–88
    17. Romanos GE, Henze M, Banihashemi S, Parsanejad HR, Winckler J, Nentwig GH. Removal of epithelium in periodontal pockets following diode (980 nm) laser application in the animal model: an in vitro study. Photomed Laser Surg. 2004 Jun;22(3):177–83. [PubMed]
    18. Fei Tang, Ye Zhang, Juan Zhang, Junwei Guo,” Assessment of the efficacy of laser hyperthermia and nanoparticle-enhanced therapies by heat shock protein analysis”, 2014 AIP Advances 4, 031334. 
Iranian Journal of Medical Physics
Volume 16, Issue 4 - Serial Number 4
July and August 2019
Pages 314-318

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History

  • Receive Date: 06 April 2018
  • Revise Date: 02 December 2018
  • Accept Date: 02 December 2018

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