Improvement ability of EIT for Thermal monitoring during Thermal Therapy by gold nanoparticles

Document Type: Conference Proceedings

Authors

1 Assistant Professor, Department of Medical Physics and Biomedical Engineering, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Professor, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.

3 M.D. Assistant Professor, Department of Radiology, school of medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Assistant Professor, Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

5 Nanotechnology Research Center, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Associate Professor, Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Introduction: To prevention the healthy tissues from irreversible damages, monitoring the temperature variation of healthy tissues is critical parameter during thermal therapies. Electrical impedance tomography (EIT) is considered as a real time imaging modality for monitoring the temperature but researches show that it suffers from low temperature resolution. In this study using of gold nanoparticles(GNPs) to increase the EIT signal variation due to change in temperature of tissues was studied and improvement of its temperature resolution was surveyed.
Materials and Methods: Spherical GNPs with size of 20-25 nm were synthesized with Turkevich method. Size distribution and shape of these NPs was characterized by transmission electron microscopy (TEM). EI of muscle and fat tissues at different temperatures were measured and compared to their EI at presence of GNPs.
Results: EI of tissues decrease (electrical conductance increase) as their temperature increase and GNPs cause to intensify this phenomenon. Increase in specific conductance of fat and muscle
tissues at   360 C were   3.80´10-3 S m and 8.59´10-2 S m, respectively.  These  values were
15.1% and 13.2% for fat and muscle tissues, respectively.
Conclusion: Presence of GNPs could lead to increase the variation of EIT signal intensity due to change of temperature. Therefore, considering the temperature changes followed to use of GNPs in thermal treatment is recommended.

Keywords