Shahin, H., Attalla, E., Abouelenein, H., Elsayed, H., Bashter, I. (2018). A comparative study between three-dimensional conformal radiotherapy and intensity modulated radiotherapy for craniospinal irradiation. Iranian Journal of Medical Physics, (), -. doi: 10.22038/ijmp.2018.28016.1326
Hadeer Shahin; Ehab Attalla; Hassan Shafik Abouelenein; Hussein Elsayed; Ibrahim Ismail Bashter. "A comparative study between three-dimensional conformal radiotherapy and intensity modulated radiotherapy for craniospinal irradiation". Iranian Journal of Medical Physics, , , 2018, -. doi: 10.22038/ijmp.2018.28016.1326
Shahin, H., Attalla, E., Abouelenein, H., Elsayed, H., Bashter, I. (2018). 'A comparative study between three-dimensional conformal radiotherapy and intensity modulated radiotherapy for craniospinal irradiation', Iranian Journal of Medical Physics, (), pp. -. doi: 10.22038/ijmp.2018.28016.1326
Shahin, H., Attalla, E., Abouelenein, H., Elsayed, H., Bashter, I. A comparative study between three-dimensional conformal radiotherapy and intensity modulated radiotherapy for craniospinal irradiation. Iranian Journal of Medical Physics, 2018; (): -. doi: 10.22038/ijmp.2018.28016.1326
A comparative study between three-dimensional conformal radiotherapy and intensity modulated radiotherapy for craniospinal irradiation
Articles in Press, Accepted Manuscript, Available Online from 13 December 2018
1Faculty of science;Department of physics;Zagazig university; Zagazig,Egypt
2Prof. of Medical physics ; National Cancer Institute, cairo university & children'n Cancer Hospital ,Egypt
3Consultant of Medical physics; children cancer Hospital, Egypt
4Medical Physicist ; children cancer Hospital, Cairo
5Prof Of Nuclear Physics; Faculty of science;Zagazig University, Egypt
Receive Date: 28 March 2018,
Revise Date: 10 December 2018,
Accept Date: 13 December 2018
Abstract
Introduction: Craniospinal irradiation is considered a very important element in medulloblastoma treatment. The aim of this study is to compare dosimetric parameters of intensity-modulated radiation therapy (IMRT) and three- dimensional conformal radiotherapy (3DCRT) for craniospinal irradiation (CSI) in the treatment of medulloblastoma. Materials and Methods: Plans were created for thirteen medulloblastoma patients using two techniques, three dimensional conformal radiotherapy (3DCRT) and intensity modulated radiotherapy using linear accelerator (IMRT).The prescribed dose of the planning target volume was 2340Gy in 13 fractions. Target coverage was evaluated with the Dmean, D95%, D2%.D98% and V95%.Homogeneity index (HI), integral dose (ID) and doses to the organs at risk (OARs) were also compared. Results: For PTV-Brain: 3DCRT plans resulted a higher Dmean, D95% D98%, D2% and V95% (24.35Gy, 94.33%, 89.21%, 104% and 94.73% respectively) compared to the IMRT plans (23.41Gy, 94.21%, 88.83%, 105% and94.94% respectively). While for PTV-Spine: IMRT plans resulted a higher Dmean, D95% D98%, D2% and V95% (24.8Gy,97.38%,95.65%,106.28% and 98.27% respectively) compared to the 3DCRT plans (24.6Gy, 94.73%, 92.51%, 106.21% and94.13 respectively). All plans resulted in a comparable dose homogeneity index (DHI) for PTV-Brain. For PTV-Spine, IMRT technique improved dose homogeneity compared to 3DCRT technique (1.09 vs. 1.12; p>0.05).3DCRT delivered lower dose for OARs, except the heart and thyroid IMRT achieved better sparing. Conclusions: Dose coverage of the planning target volume (PTV) and organ at risk (OAR) was better with IMRT plans, but 3DCRT reduced mean dose to most OARS, except the heart and thyroid. Therefore; IMRT technique may be a CSI treatment alternative to 3DCRT.
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