Comparison of Dosimeters Between Radionuclides in Brachytherapy for Liver Cancer

Document Type: Conference Proceedings

Authors

Department of medical radiation Science and Research, Islamic Azad University, Tehran Iran

Abstract

Introduction: One of the methods for treating metastatic primary liver cancer is brachytherapy, using 90Y

with a half-life of 64.1 hours and an energy of 2.28MeV and decay 𝛽   is a good treatment
for treating HCC Liver cancer. But brachytherapy using 90Y because the dose distribution and dose concentration in the tumor and organs surrounding the tumor can not be seen in treatment and Images are taken with radionuclide using SPECT or annihilation radiation using PET and Chernokov radiation, have problems such as low resolution and imaging difficulty. Therefore, to solve this problem, use radionuclides such as 153Sm with a half-life of 46.3 hours and 177Lu with a half life of 6.71 days and 166Ho with a half-life of 26.8 hours
.
Materials and Methods: here ecause of the high precision of voxel phantoms ICRP110 is used for dosimetry calculations. And these phantoms include the whole female body phantom with height and weight of 163cm and 60kg, which consists of more than 14 million voxels, and the female phantom voxel is 1.775mm * 1.775mm * 4.8mm. In this phantom, the bone tissue is comprised of compressed bone and the red and yellow bone marrow and the weight percentages of blood are also calculated for any soft tissue, and due to the accuracy and resolution of this phantom, it is suitable for simulating and calculating the internal dosimeter. Using the fluka code in Monte Carlo, given the precise and resolution of this phantom, it can simulate the human body to calculate the internal dosimetry. Calculated with radionuclides 90Y, 153Sm, 177 Lu, 166Ho, and the amount of doses in the liver and around the liver (kidneys, lungs, heart, stomach, pancreas, vesicles, and bone marrow).
Results: By comparing organs between Liver, lung right, lung left, Heart contents, ribs cortical, ribs spongiosa, Heart wall, Gallbladder contents, kidney cortex right, stomach contents, pancreas stomach wall, spleen, kidney cortex left, Gallblladder wall kidney medulla right, , ,kidney medulla left,kidney pelvis right, kidney pelvis left , The highest dose is for the liver and the right lung And the lowest for kidney pelvis right kidney pelvis left. Conclusion:  Here we compare radionuclide to find best for treatment.

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