Document Type: Conference Proceedings
Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Imam Reza University Hospital, Radiotherapy Department, Tabriz, Iran
Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Imam Reza University Hospital, Radiotherapy Department, Tabriz, Iran
Introduction: Nanoparticles have several exciting applications in various fields of biomedicine. It has been found that among different classes of nanoparticles core/shell is most promising for field of nano-medical imaging and therapy due to their distinct advantages. The core/shell type nanoparticles can be generally comprising of two nanoparticles one act as a core (inner material) and the second act as a shell (outer layer material). the aim of this study in brief is to explore a historical review of the core/shell nanoparticles in past two decades.
Materials and Methods: An organized search of Web of Science, Google Scholar and Scopus was made to select papers with different classes of Core/Shell nanoparticles from the time of introduction to August 2017. The search was limited to English language documents. Titles and abstracts were carefully assessed.
Results: Eighty - nine studies were considered as relevant for this review. Of these 64, 18 and 7 studies were classified as inorganic/inorganic, inorganic/organic or organic/inorganic, and organic/organic material core/shell nanoparticles. In general, it is considering that inorganic/inorganic (metal or metal-oxide) core/shell nanoparticles are the most common and important class of all the different types of core/shell nanoparticles but still there are lots of work need to be done in order to verify their applications.
Conclusion: It seems that, core/shell nanoparticles have strikingly superior over simple nanoparticles and also the inorganic/inorganic core/shell nanoparticles are extensively studied due to their wide applications in cancer treatment, bio imaging and cell targeting.