Document Type: Conference Proceedings
MSC of Radiobiology & Radiation Protection, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. E-mail address . Tel: +98 9104593624
Assistant Professor of Medical Physics, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Associate Professor of Medical Physics, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor of Pathology, Diagnostic Laboratory Sciences and Technology Research Center, Basic Sciences in Infection Diseases Research Center, Center of Comparative & Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: Despite the extensive use of ionizing radiation in diagnosis and therapeutic procedures, development of radio-protector agents is important in modulating normal tissue damages. Hesperidin(HES) is a Flavanone glycoside, belonging to the Flavonoid family in human diet abundantly and noted for its many beneficial effects. The aim of present study was investigated to the radio-protective effects of Hesperidin on radiation-induced hepatotoxicity in male Sprague Dawely rat.
Materials and Methods: 40 male Sprague Dawley rats were selected randomly and divided into 8groups: control, Hesperidin (100 mg/kg body weight, orally, 7 days), whole body gamma radiation with 2 Gy and 8 Gy, pre-administrated with 50 and 100 mg/kg body weight of Hesperidin for 7 days before irradiation with 2Gy and 8 Gy, respectively. Histopathological evaluation was done 24 h after radiation.
Results: Administration of Hesperidin (50 and 100 mg/kg b.w, orally, 7 days) before 2 Gy of gamma radiation led to remove inflammatory mononuclear cells in the portal space but there was still dilation of central veins while hesperidin at a dose of 100 mg/kg before 2 Gy gamma radiation was observed normal liver structure. Microscopic findings in the groups in the groups receiving two doses of Hesperidin (50 and 100 mg/kg b.w , orally, 7 days) before 8 Gy of gamma radiation was similar , in this way that extreme dilation of central veins to be seen but there was no capillarization.
Conclusion: Based on the finding in this study, it shows that Hesperidin would ameliorate the radiation-induced damage. Therefore, HES may be offered as suitable radio-protector in radiotherapy patients, radiation workers and public.