Document Type: Conference Proceedings
Ahvaz Jundishapur university of medical sciences, medical physics department, Ahvaz, Iran
Quantitative assessments of the effects induced by repetitive transcranial magnetic stimulation (rTMS) are crucial to develop more efficient and personalized treatments. Objectives: To determine the spectral powers of different subbands of EEG correlated with treatment response to rTMS.
Materials and Methods:
the spectral powers of different subbands of EEG correlated with treatment response to rTMS. Methods: In an open label study 10 patients with intractable major depression received a ten session 20 Hz rTMS over left dorsolateral prefrontal cortex. The EEGs were recorded in all subjects prior and post intervention using a 19-channel EEG system. Hamilton depression rating scale (HAM-D) was also used to determine treatment response. The rTMS protocol consisted of daily one session of 60 trains (2.5 s, inter-train of 17.5 s) at 120% MT for 5 consecutive days per week and 2 weeks. Absolute and relative powers in all electrodes for delta (0-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), sensorimotor rhythm (SMR)(12-15 Hz), beta (15-20 HZ), and high beta (20-28 Hz) were compared prior and post intervention in the responders. Spectral powers of prefrontal and sensorimotor regions of brain predict response to repetitive transcranial magnetic stimulation
In the responders (n=5), absolute powers of alpha in F3, F4, C3, and C4 electrodes, absolute power of theta and alpha sub-bands in C4 electrode significantly changed (P<0.05). In the SMR band, absolute powers in the Fp1, Fp2, F3, F4, F7, FZ, C3, and C4 significantly changed (P<0.05). In beta subband, relative power in C4 and absolute power in Fp1, Fp2, F4, CZ, and C4 significantly changed (P < 0.05).
The spectral powers of particular sub-bands in prefrontal cortex and sensorimotor areas can predict response to rTMS treatment.