Effective dose assessment in body organs after injection of 131I-MIBG

Document Type: Conference Proceedings

Authors

1 Department of Nuclear Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran

2 Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.

Abstract

Introduction:
Development of a novel radiopharmaceutical needs assessment of its biological- distribution in animal models, most commonly mice prior to its common application.
This study describes the biodistribution and absorbed dose prediction 131I-MIBG in human organs after injection in mice.
 
Materials and Methods:
In this research, 131I-MIBG radiopharmaceutical was injected to mice. After 4, 12, 24, and 48 hours post injection, the mice sacrificed and its organs dissected and counted by well detector. Then with having the Injected dose per gram of organs, absorbed dose of organs was calculated by MCNP simulation code and MIRD methods.
 
Results:
The results showed that the intestine and thyroid organs absorbed the least and most dose after injection of 131I-MIBG in mice.
 
Conclusion:
Many studies have demonstrated the usefulness of using animal distribution as a model for absorbed dose estimations in humans. Radiation dosimetry for 131I-MIBG was estimated for humans based on the biodistribution data in normal mice. The obtained results by MIRD and MCNP had shown close results.

Keywords