A comparative Study of 3-D Conformal Radiotherapy Treatment Plans with and without Deep Inspiration Breath Hold Technique for Left-Sided Breast Cancer

Document Type: Technical Notes

Authors

1 Physics Department, Faculty of Sciences, Suez Canal University

2 Prof. of Medical physics ; National Cancer Institute, cairo university & children'n Cancer Hospital ,Egypt

3 Professor of Physics, Physics Department, Faculty of Science (Ismailia) Suez Canal University

Abstract

The rate of cardiac diseases for the patients underwent radiotherapy for left-sided breast cancer have increased in compare to right-sided breast cancer. The aim of this study is to compare the dose to organs at risk in free breathing 3-dimensional conformal (FB-3DCRT) vs 3-dimensional conformal deep inspiration breath hold (3DCRT-DIBH) for patients with left-sided breast cancer. 3DCRT-DIBH was used to minimize cardiac irradiation Fifteen female patients diagnosed with left-sided breast cancer from December 2017 to December 2018. All selected patients submitted 2 computed tomography (CT) scans: free breathing (FB) and DIBH CT-scan. 3DCRT plans were created on both DIBH and FB scans for each selected patient used standard tangents. Various doses were obtained from dose volume histograms (DVH) and then compared. The statistical package for the social sciences (SPSS) version 20 (IBM; IL) was used for data analysis and statistics. p-value of < 0.05 considered as the limit for significance. By comparing the results of DIBH and FB condition. The average maximum dose and V95% for PTV were approximate for both DIBH and FB and the average mean doses to the heart, left anterior descending LAD and left Lung were decreased by 40.50%. (p= 0.0003), 54.30% (p=0.02) and 18.50% (p=0.0002) in respectively in DIBH. And the heart V25% and V30% were decreased by 36% (p= 0.06) and 35.8 % (p= 0.03) respectively in DIBH. The Left Lung V10 % and V20 % were decreased by 18.10 % (p=0.0006) and 18 % (p=0.0002) respectively in DIBH.
3DCRT-DIBH for patients with left-sided breast cancer maintaining the benefits of radiotherapy while minimizing cardiac risks. All patients concluded smoothly their treatment.

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Articles in Press, Accepted Manuscript
Available Online from 05 July 2019
  • Receive Date: 02 May 2019
  • Revise Date: 27 June 2019
  • Accept Date: 05 July 2019