Document Type: Original Paper
Department of Radiology, School of Paramedical Sciences, Shiraz University of medical Sciences, Shiraz, Iran
Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz University of Medical Sciences - shiraz - Iran
Shiraz University of Medical Sciences, Shiraz, Iran
Introduction: Long-term use of fluoroscopy in cardiac interventional procedures increases the patient's dose and causes severe skin reactions which lead to increased concern. The aim of the present study was to evaluate the risk and the effects of X- ray irradiation on apoptosis in the peripheral blood lymphocytes of patients treated with ablation in electrophysiology studies.
Materials and Methods: Thirty patients with ablation therapy participated in this study. The absorbed dose in the given area was measured by Thermo Luminescent Dosimeter (TLD). Duration of dose delivery, absorbed dose by the apparatus and dose area product factor were measured for each patient. The skin changes were observed from one day to five weeks after operation. Blood sampling was done (pre and 24hrs post treatment), and then the flow cytometry was performed to investigate the apoptotic changes in the blood lymphocytes.
Results: The statistical analysis showed that there was a significant difference in the apoptosis of patient's blood lymphocytes before irradiation and after that (P < 0.05). There was correlation between the amount of dose area product (DAP) and TLD dose (p < 0.001). Furthermore, there was correlation between the total apoptosis and fluoroscopic time. Patient's radiation dose in ablation test was not in the threshold level needed to create skin erythema.
Conclusions: This study, suggest that Long-time fluoroscopy in electrophysiological study may cause a significant increase of apoptosis in peripheral blood lymphocyte of patients that treated with this procedure.