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Pourfallah, T., Allahverdi, M., Zahmatkesh, M. (2012). Evaluation of the Effects of Inhomogeneities on Dose Profiles Using Polymer Gel Dosimeter and Monte Carlo Simulation in Gamma Knife. Iranian Journal of Medical Physics, 9(1), 1-8. doi: 10.22038/ijmp.2012.321
Tayeb Allahverdi Pourfallah; Mahmoud Allahverdi; Mohammad Hasan Zahmatkesh. "Evaluation of the Effects of Inhomogeneities on Dose Profiles Using Polymer Gel Dosimeter and Monte Carlo Simulation in Gamma Knife". Iranian Journal of Medical Physics, 9, 1, 2012, 1-8. doi: 10.22038/ijmp.2012.321
Pourfallah, T., Allahverdi, M., Zahmatkesh, M. (2012). 'Evaluation of the Effects of Inhomogeneities on Dose Profiles Using Polymer Gel Dosimeter and Monte Carlo Simulation in Gamma Knife', Iranian Journal of Medical Physics, 9(1), pp. 1-8. doi: 10.22038/ijmp.2012.321
Pourfallah, T., Allahverdi, M., Zahmatkesh, M. Evaluation of the Effects of Inhomogeneities on Dose Profiles Using Polymer Gel Dosimeter and Monte Carlo Simulation in Gamma Knife. Iranian Journal of Medical Physics, 2012; 9(1): 1-8. doi: 10.22038/ijmp.2012.321

Evaluation of the Effects of Inhomogeneities on Dose Profiles Using Polymer Gel Dosimeter and Monte Carlo Simulation in Gamma Knife

Article 1, Volume 9, Issue 1, March 2012, Page 1-8  XML PDF (510 K)
Document Type: Original Paper
DOI: 10.22038/ijmp.2012.321
Authors
Tayeb Allahverdi Pourfallah 1; Mahmoud Allahverdi2; Mohammad Hasan Zahmatkesh3
1Biochemistry and Biophysics Dept., Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2Medical Physics Dept., Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Novin Medical Radiation Institute, Tehran, Iran
Abstract
Introduction
Polymer gel dosimeters offer a practical solution to 3D dose verification for conventional radiotherapy as well as intensity-modulated and stereotactic radiotherapy. In this study, EGSnrc calculated and PAGAT polymer gel dosimeter measured dose profiles from single shot irradiation with 18 mm collimator of Gamma Knife in homogeneous and inhomogeneous phantoms were compared with each other.
Materials and Methods
The head phantom was a custom-built 16 cm diameter plexiglas sphere. Inside the phantom, there were two cubic cutouts for inserting the gel vials and inhomogeneities. Following irradiation with the Gamma Knife unit, the polymer gel dosimeters were scanned with a 1.5 T MRI scanner. For the purpose of simulation the simplified channel of 60Co source of Gamma Knife BEAMnrc and for extracting the 3D dose distribution in the phantom, DOSXYZnrc codes were used.
Results
Within high isodose levels (>80%), there are dose differences higher than 7%, especially between air inserted and PTFE inserted phantoms, which were obtained using both simulation and experiment. This means that these values exceed the acceptance criterion of conformal radiotherapy and stereotactic radiosurgery (i.e., within some isodose levels, less than 93% of prescription dose are delivered to the target).
Conclusion
The discrepancies observed between the results obtained from heterogeneous and homogeneous phantoms suggest that Leksell Gamma Knife planning system (LGP) predictions which assume the target as a homogeneous material must be corrected in order to take care of the air- and bone-tissue inhomogeneities.
Keywords
Dose Profile; Gamma Knife; Inhomogeneity; Monte Carlo; Polymer Gel Dosimeter
Main Subjects
Medical Physics; Physics of Radiotherapy; Radiation Detection & Measurement
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