TY - JOUR ID - 15657 TI - Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation JO - Iranian Journal of Medical Physics JA - IJMP LA - en SN - AU - Fardid, Reza AU - Fazilatpour, Hossein AU - Ebrahimi, Narges AU - Sadeghi, Ali AU - Zare, Tahereh AD - Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran AD - Student Research Committee, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2021 PY - 2021 VL - 18 IS - 2 SP - 117 EP - 122 KW - Lycopene KW - Curcumin KW - Radiation KW - Micronucleus Assay DO - 10.22038/ijmp.2020.44248.1676 N2 - Introduction: Today, the use of ionizing radiation in medicine has grown as an important tool for diagnosis and treatment of diseases. However, the harmful effects of radiation should be also considered. Some substances such as lycopene and curcumin can reduce or increase the harmful effects of radiation on humans. So the aim of this study was to evaluate the radioprotective effects of lycopene and curcumin based on the MN assay. Material and Methods: In this study, the effects of lycopene and curcumin on reducing or increasing the harmful effects of radiation were studied using the micronucleus assay. The effects of lycopene (5 μg/mL) and curcumin (5 μg/mL) were evaluated at radiation doses of 2 and 6 Gy. Results: The results indicated that the simultaneous use of curcumin and lycopene can be radioprotective at low radiation doses (2 Gy; p <0.001) and radiosensitizing at high doses (6 Gy; P>0.05). Conclusion: Based on the present results, further research using other methods may contribute to our understanding of the effect of simultaneous use of curcumin and lycopene at low and high doses of X-ray radiation. UR - https://ijmp.mums.ac.ir/article_15657.html L1 - https://ijmp.mums.ac.ir/article_15657_97257f09817337e14e3dd8161538420c.pdf ER -