TY - JOUR ID - 20602 TI - On Prediction of Cardio-Pulmonary Complications during Hypofractionated versus Conventional Fractionated Regimens of Left Breast Radiation Therapy Using Monte Carlo and Collapsed Cone Convolution Based Algorithms JO - Iranian Journal of Medical Physics JA - IJMP LA - en SN - AU - Omidvar, Sepideh AU - mostafanezhad, kamal AU - Zeinali, Ahad AD - Department of Medical Physics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. AD - Omid Research and Treatment Center, Urmia, Iran Y1 - 2023 PY - 2023 VL - 20 IS - 3 SP - 168 EP - 176 KW - Breast Neoplasms Pulmonary Heart Disease Radiation Dose Hypofractionation Radiotherapy Planning Computer KW - Assisted DO - 10.22038/ijmp.2022.62939.2066 N2 - Introduction: Due to the challenge of choosing the optimal treatment regimen as well as the accurate dose calculation algorithm (DCA), this study aimed to evaluate the DCAs to compare the conventional fractionation radiotherapy (CFRT) and hypofractionation radiotherapy (HFRT) of breast cancer (BC) in the prediction of cardio-pulmonary complications. Material and Methods: For 19 patients with left-sided BC, treatment regimens, CFRT (50Gy/25frs) vs. HFRT (42.5Gy/16frs), were simulated. Normal tissue complication probability (NTCP) and tumor control probability (TCP) values for each regimen using radiobiological models were calculated via Monte Carlo (MC) and Collapsed Cone Convolution (CCC) algorithms. For statistical comparison of the results obtained from the regimens and algorithms, the t-test and Wilcoxon test were used in SPSS Statistics. Statistical significance was defined as p<0.05. Results: The mean NTCP and TCP calculated in CFRT and HFRT were as follows: cardiac mortality (MC: CFRT=0.0374±0.0134 vs. HFRT=0.0173±0.0066; p<0.001) and (CCC: CFRT=0.0373±0.0134 vs. HFRT=0.0168±0.0064; p<0.001), pneumonitis (MC: CFRT=0.1201±0.0322 vs. HFRT=0.0756±0.0221; p<0.001) and (CCC: CFRT=0.1131±0.0310 vs. HFRT=0.0697±0.0120; p<0.010), and TCP (MC: CFRT=0.9979±0.0087 vs. HFRT=0.9997±0.0092; p=0.593) and (CCC: CFRT=0.9982±0.0029 vs. HFRT=0.9986±0.0016; p=0.821). Conclusion: The comparison of CFRT and HFRT using MC and CCC algorithms showed that the risk of cardiac mortality and pneumonitis in CFRT was significantly higher than in HFRT, and TCP was not significantly different in the two regimens. Applications of MC-based DCAs along with suitable biological parameters can help physicists in the prediction of radiation-induced complications accurately and precisely. UR - https://ijmp.mums.ac.ir/article_20602.html L1 - https://ijmp.mums.ac.ir/article_20602_fe6c6a44e4dba0fe469c98ce429a3955.pdf ER -