Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Transfer of Radio-Adaptation via Serum: A Preliminary Report

Document Type : Original Paper

Authors
Ehsan Khodamoradi 1
Rasool Azmoonfar 2
Mohammad Mohammadi 1
Amir Kiani 3
Abbas Haghparast 4
Nasrin Sharafi 1
Loghman Diojan 1
1 Department of Radiology and Nuclear Medicine, Faculty of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Radiology, Faculty of Paramedical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
3 Associate Professor, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Associate Professor of Medical Physics, Department of Medical Physics, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
10.22038/ijmp.2019.39821.1532
Abstract
Introduction: Adaptive response is one of the important concepts in radiobiology. The present report aimed to transfer the radio-adaptation via serum.
Material and Methods: In total, 50 male adult Wistar rats were randomly divided into 6 groups, including control, serum control, low-dose (100cGy), low-dose/lethal, serum/lethal, and lethal (8Gy). Exposure was carried out by a linear accelerator (Elekta Synergy® Platform) with a 40×40cm field size. The animals were monitored in terms of the endpoints of the survival rate, and at the first stage, the rats were exposed to the low doses of radiation. Subsequently, the serum was injected intraperitoneally under sterile conditions 6 h after low-dose exposure. The Kaplan Meier Survival Curve was used to evaluate the survival rate (p <0.05).
Results: There was a significant difference among different groups regarding the survival rates. Moreover, a statistically significant difference was observed between low-dose/lethal and low-dose/serum, low-dose/lethal and lethal, and low-dose/serum and lethal (P=0.001). Similarly, there was a statistically significant difference between the control and experimental groups regarding the survival rates (P=0.001).
Conclusion: To the best of our knowledge, this method can lead to immunological responses or unknown mechanisms that result in the increased survival adaptive response to subsequent high-dose radiation.
Keywords
Adaptive Response
Radiation Effects
Serum
Survival Rate
Subjects

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Iranian Journal of Medical Physics
Volume 17, Issue 5
September and October 2020
Pages 316-321

  • Receive Date 22 April 2019
  • Revise Date 11 October 2019
  • Accept Date 15 October 2019