Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

The Effect of Cobalt Oxide Nanoparticles on Improving the Quality of Computerized Tomography (CT) Scan Medical Imaging

Document Type : Original Paper

Authors
Mohamdreza Armanmehr 1
Mohammadreza Jalali 1
Ali Asghar Shokri 1
Ali Heydari Chaleshtori 2
1 Department of Physics, Payam Noor University (PNU), Tehran, Iran
2 Department of Biomedical Engineering, Payam Noor University (PNU), Tehran, Iran
10.22038/ijmp.2021.59219.1996
Abstract
Introduction: Sometimes, a patient receives a poor quality medical image from a medical imaging center. Which the doctor orders to re-image with a drug contrast media agent. At this time, practical action is challenging to provide a proper image. Cobalt oxide nanoparticles show different activities based on different sizes and shapes. Objectives of this project is achievement a critical size of cobalt oxide nanoparticles between 5 to 10 nanometers for easy circulation in the blood and   Investigation of the effect of cobalt oxide nanoparticles on the quality of CT from laboratory mice(Mus musculus).
Material and Methods: In this study, the coupling method was used to prepare the cobalt oxide nanoparticles. Co3O4 nanoparticle coatings are used for this purpose. They were investigated through the Fourier-transform infrared (FTIR) analysis, X-rays diffraction (XRD). In order to investigate the efficacy of cobalt oxide nanoparticles, we injected a suspension into the Mus musculus, and then the computerized tomography (CT) scans were taken before and after injection of the nanoparticles. Then, quantity evaluation was performed using the calculating the average local contrast media of the whole image.
Results: The average size of cobalt oxide nanoparticles was obtained about 5.8 nm, which is an appropriate size in the nanometer scale. After injecting of cobalt oxide nanoparticles into the mice and then CT scan imaging, we have obtained a better clarity.
Conclusion: Cobalt oxide nanoparticles behave well for use as a pharmacological contrast media agent in CT scan imaging.
Keywords
Contrast Media Neoplasms Nanoparticles Computerized Tomography X
Rays
Subjects
  1. Suetens P. Fundamentals of medical imaging. Cambridge university press; 2017 May 11.
  2. Jackson P, Periasamy S, Bansal V, Geso M. Evaluation of the effects of gold nanoparticle shape and size on contrast media enhancement in radiological imaging. Australasian Physical & Engineering Sciences in Medicine. 2011 Jun;34(2):243-9.
  3. Tade FI, Sajdak RA, Gabriel M, Wagner RH, Savir-Baruch B. Best practices for 18F-fluciclovine PET/CT imaging of recurrent prostate cancer: a guide for technologists. Journal of Nuclear Medicine Technology. 2019 Dec 1;47(4):282-7.
  4. Clark DP, Ghaghada K, Moding EJ, Kirsch DG, Badea CT. In vivo characterization of neoplasms vasculature using iodine and gold nanoparticles and dual energy micro-CT. Physics in Medicine & Biology. 2013 Feb 19;58(6):1683.
  5. Maccora D, Dini V, Battocchio C, Fratoddi I, Cartoni A, Rotili D, Castagnola M, Faccini R, Bruno I, Scotognella T, Giordano A. Gold nanoparticles and nanorods in nuclear medicine: A mini review. Applied Sciences. 2019 Jan;9(16):3232.
  6. Ahmadi R, Shaeri M. Production and application of iodinated iron oxide nanoparticles for CT-MR dual medical imaging. 2018; 30(9): 121-9.
  7. Fernández-Barahona I, Muñoz-Hernando M, Herranz F. Microwave-driven synthesis of iron-oxide nanoparticles for molecular imaging. Molecules. 2019 Jan;24(7):1224.
  8. William WY, Falkner JC, Yavuz CT, Colvin VL. Synthesis of monodisperse iron oxide nanocrystals by thermal decomposition of iron carboxylate salts. Chemical Communications. 2004(20):2306-7.
  9. Xie J, Chen K, Huang J, Lee S, Wang J, Gao J, Li X, Chen X. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials. 2010 Apr 1;31(11):3016-22.
  10. Even-Sapir E, Bettman L, Iosilevsky G, Milshtein D, Frenkel A, Kolodny GM, Ben-Haim S, Israel O. SPECT quantitation of cobalt-57-bleomycin to predict treatment response and outcome of patients with lung cancer. Journal of Nuclear Medicine. 1994 Jul 1;35(7):1129-33.
  11. Jalilian AR, Rowshanfarzad P, Moafian J, Ensaf MR, SAbet MA. Preparation and Quality Control of Radiolabelled Cobalt-57 Bleomycins for Oncological Studies. Journal of Nuclear Science and Technology (JonSat). 2006 Nov 22;26(3):1-6.
  12. Magaye R, Zhao J, Bowman L, Ding M. Genotoxicity and carcinogenicity of cobalt-, nickel-and copper-based nanoparticles. Experimental and therapeutic medicine. 2012;4(4):551-61.
  13. Huang X, Cai H, Zhou H, Li, T, Jin H, Evans CE, et al. Cobalt oxide nanoparticle-synergized protein degradation and phototherapy for enhanced anticancer therapeutics. Acta Biomater. 2021; 121: 605–
  14. Maria S, Claudiu M, Izabell C, Sergiu G. In vivo distribution of poly(ethylene glycol) functionalized iron oxide nanoclusters: An ultrastructural study. Nanomaterials. 2021 ;11, 2184.
  15. Irene F, María M, Juan P. Molecular imaging with 68Ga radio-nanomaterials: shedding light on nanoparticles; Appl. Sci. 2018; 8: 1098.
  16. Yarestani M, Khalaji AD, Rohani, Das D. Hydrothermal synthesis of cobalt oxide nanoparticles: Its optical and magnetic properties. Journal of Sciences Islamic Republic of Iran. 2014; 25(4): 339- 43.
  17. Bushberg JT, Seibert JA, Leidholdt EM, Boone JM. The essential physics of medical imaging. 3rd ed. Philadelphia: Lippincott Williams & Wikings; 2012.
  18. Matković K, Neumann L, Neumann A, Psik T, Purgathofer W. Global contrast media factor - a new approach to image contrast media. Proceedings of the First Eurographics conference on Computational Aesthetics in Graphics, Visualization and Imaging. In: Neumann L, Sbert M, Gooch B, Purgathofer W. The Eurographics Association 2005. Girona, Spain; May 2005; 159-67.

 

 

 

 

Iranian Journal of Medical Physics
Volume 19, Issue 3
May and June 2022
Pages 154-158

  • Receive Date 28 July 2021
  • Revise Date 16 October 2021
  • Accept Date 04 November 2021