Document Type : Original Paper
Department of Physics, Payam Noor University (PNU), Tehran, Iran
Department of Biomedical Engineering, Payam Noor University (PNU), Tehran, Iran
Introduction: Sometimes, a patient receives a poor quality medical image from a medical imaging center. Which the doctor orders to re-image with a drug contrast media agent. At this time, practical action is challenging to provide a proper image. Cobalt oxide nanoparticles show different activities based on different sizes and shapes. Objectives of this project is achievement a critical size of cobalt oxide nanoparticles between 5 to 10 nanometers for easy circulation in the blood and Investigation of the effect of cobalt oxide nanoparticles on the quality of CT from laboratory mice(Mus musculus).
Material and Methods: In this study, the coupling method was used to prepare the cobalt oxide nanoparticles. Co3O4 nanoparticle coatings are used for this purpose. They were investigated through the Fourier-transform infrared (FTIR) analysis, X-rays diffraction (XRD). In order to investigate the efficacy of cobalt oxide nanoparticles, we injected a suspension into the Mus musculus, and then the computerized tomography (CT) scans were taken before and after injection of the nanoparticles. Then, quantity evaluation was performed using the calculating the average local contrast media of the whole image.
Results: The average size of cobalt oxide nanoparticles was obtained about 5.8 nm, which is an appropriate size in the nanometer scale. After injecting of cobalt oxide nanoparticles into the mice and then CT scan imaging, we have obtained a better clarity.
Conclusion: Cobalt oxide nanoparticles behave well for use as a pharmacological contrast media agent in CT scan imaging.