Evaluation of Low-Dose 3D skull CT images in craniosynostosis

Document Type : Original Paper


1 Medical imaging research center, Shiraz university of medical sciences, Shiraz, Iran

2 Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran

3 Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 560012. INDIA

4 Indian Institute of Astrophysics, Bangalore

5 Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


Introduction: Computed Tomography (CT) is nowadays used widely to differentiate normal brain cranium sutures from abnormal ones in pediatric patients with the aim of early treatment. This study tried to develop a low-dose CT protocol with acceptable image quality of skull bone in order to evaluate craniosynostosis.

Materials and Methods: In this study a cranium bone of human cadaver was scanned with standard and reduced dose protocols. Two radiologists verified the quality of skull bone image acquired from the protocol in which there had been 60% dose reduction to scan pediatric patients. The quality of low dose protocol of three dimensional (3D) CT images of skull bone of 57 pediatric subjects suspected of craniosynostosis were compared with standard-dose skull CT images of 44 patients of the same age range. Volume CT dose index (CTDIvol), dose-length product (DLP), and effective dose (ED) were used to evaluate CT dose protocols. Comparison was made by two sample t-test.

Results: Mean and standard deviations of CTDIvol, DLP, and ED of standard and reduced doses were 12.4±2.7 mGy, 191.5±54 mGy.cm, 1.94±0.58 mSv and 5.4±0.2 mGy, 85±9 mGy.cm, 0.77±0.17 mSv, respectively, which had statistically significant difference (α=0.05). The quality of skull bone views obtained from low-dose CT protocol were found to be as good as in standard dose.

Conclusion: Standard-dose 3D CT protocol of skull bone can be replaced by a 60%-reduced-dose 3D CT protocol with comparable image quality in pediatric patients suspected of craniosynostosis.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 04 November 2021
  • Receive Date: 01 August 2021
  • Revise Date: 29 October 2021
  • Accept Date: 04 November 2021
  • First Publish Date: 04 November 2021