Simulation Study on the Effect of High Intensity focused Ultrasound on Thermal Lesion of Biological Tissue under Different Treatment Modes

Document Type : Original Paper

Authors

1 School of Information Science and Engineering, Changsha Normal University, Changsha 410100, China

2 School of Physics and Electronics, Central South University

3 School of Information Science and Engineering, Changsha Normal University

Abstract

High intensity focused ultrasound (HIFU) treatment is a non-invasive technology. The purpose of this study was to explore the effects of different treatment depth, tissue type and treatment interval on biological tissue thermal lesion under continuous and intermittent treatment modes.A simulation model of biological tissue irradiated by HIFU was established by finite difference time domain (FDTD). The thermal lesion of biological tissue irradiated by HIFU was calculated using spherical beam equation (SBE) and Pennes biological heat transfer equation (PBHTE). Parameters such as treatment depth, tissue type, and treatment interval were varied to explore their effects on thermal lesion to biological tissues in both continuous and intermittent treatment modes.For the same biological tissue or treatment depth, with the increase of HIFU irradiation time, the focal temperature under continuous treatment was higher than that under intermittent treatment, and the thermal lesion area under continuous treatment was greater than that under intermittent treatment. Whether continuous or intermittent treatment, with the increase of treatment depth, the temperature rise rate of deep tissue was slower than that of shallow tissue, and the thermal lesion area decreased gradually. Moreover, in the intermittent treatment mode with long single treatment time and short treatment interval, the focal temperature rase quickly and the thermal lesion area was large.For the same tissue type, treatment depth or any treatment interval, the focal temperature and thermal lesion area corresponding to continuous treatment were greater than those corresponding to intermittent treatment.

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Articles in Press, Accepted Manuscript
Available Online from 08 February 2022
  • Receive Date: 05 August 2021
  • Revise Date: 31 January 2022
  • Accept Date: 08 February 2022
  • First Publish Date: 08 February 2022