Tissue Substitute Materials for the Human Colorectal Cancer Tissue

Document Type : Original Paper

Authors

1 Department of Radiography and Radiological Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Cross River State

2 Department of Physics, Faculty of Physical Sciences, University of Calabar

3 Department of Radiography and Radiological Science, University of Calabar, Calabar-Nigeria

4 Department of Radiography and Radiological science, Faculty of allied medical sciences, University of Calabar, Calabar, Cross River State, Nigeria

5 Department of Radiography & Radiological Science, University of Calabar, Nigeria

Abstract

Introduction: Due to the high radiation dose used in radiotherapy, the human tissue is usually replaced with tissue substitute in-order to develop new treatment techniques. Tissue substitutes have not been reported for colorectal cancer tissue (CRC). This study aims at developing tissue substitutes for the CRC tissue with respect to the mass attenuation (µm) and mass energy absorption coefficients (µen/ρ) within the energy range of 6 – 15MV.

Materials and Methods: Colorectal cancer tissue and four locally sourced materials namely beewax, gelatine, rice powder, clay and their mixtures – clarice, gelarice, gelaclay and bewaclay were subjected to Rutherford Backscattering Spectrometry (RBS) to determine their elemental composition. Results from the RBS were used in XCOM, a web-based software to determine their theoretical µm and µen/ρ values within 6 – 15MV. Again, these materials were exposed to a narrow beam of x-rays at energies of 6 and 15MV to obtain their experimental µm and µen/ρ values. Theoretical and experimental values were compared to determine which local material closely matches the CRC tissue.

Results: Gelarice had the closest match to the CRC tissue in terms of the elemental composition. The ratio of the theoretical and experimental values of µm and µen/ρ revealed that bewaclay had the closest match to CRC between 6 – 9MV and at 6MV respectively.

Conclusion: Bewaclay with the closest match can be used as a tissue substitute for the CRC tissue between 6 – 9MV with respect to the use of µm and µen/ρ as parameters for matching

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Articles in Press, Accepted Manuscript
Available Online from 26 June 2022
  • Receive Date: 08 March 2022
  • Revise Date: 09 June 2022
  • Accept Date: 26 June 2022
  • First Publish Date: 26 June 2022