Blood Samples of Cancerous Patients as Biomarkers of Alpha Emitters

Document Type : Original Paper

Authors

1 Department of Physics, College of Science, University of Kerbala, 56001 Kerbala, Iraq

2 Department of Physics, Faculty of Education For Girls, University of Kufa, 54001 Kufa, Iraq

Abstract

Introduction: Radioactive contamination by uranium and its emissions, such as alpha particles, is considered one of the most critical issues affecting the human race and its existence. The study investigated the high ionization capacity number of alpha particles in whole blood samples from cancer patients because these particles have the most significant impact on the shape and function of living cells, modifying them into malignancies.
Material and Methods: The TASLImage solid nuclear trace detector CR-39 was used to measure the effects of alpha emitters in the whole blood samples from 40 cancer patients for five types of cancer (breast, uterus, prostate, kidney, and colon) collected from a government hospital at Karbala/Iraq and compared with ten healthy samples. Moreover, the research investigated whether smoking and gender variation affect the outcomes.
Results: The radon concentration in whole blood samples from patients and healthy individuals was significantly different (p< 0.05), and it was slightly higher in males with (22.82254±7.38794 Bq/m3). Women with colon cancer had higher blood levels of radon (32.13787±5.79261 Bq/m3) than men with the same malignancy (18.80531±5.63747 Bq/m3), regardless of gender. While the age factor had no noticeable impact, the smoking element had a considerable effect (p< 0.05).
Conclusion: All alpha levels were within the (ICRP) usual ranges. Women with colon cancer had the most significant alpha values. In contrast, men with the same disease had the lowest values despite cancer patients' blood levels being higher than those of the healthy group.

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References

  1. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and effects of ionizing radiation. UNSCEAR 2000 report to the General Assembly, with scientific annexes. Volume I: Sources. 2000.
  2. World Health Organization. Cancer fact sheet/ media center. [cited 2018 April 1]. Available from: http://www.who.int/mediacentre/ factsheets/fs297/en/.
  3. Hassanv H, Hassanv MS, Birjandi M. Indoor Radon Measurement in Dwellings of Khorramabad City, Iran. Iranian Journal of Medical Physics. 2018;15(1):19-8.
  4. Denton GR, Namazi S. Indoor radon levels and lung cancer incidence on Guam. Procedia Environmental Sciences. 2013 Jan 1; 18:157-66.
  5. Robertson A. Allen J .Laney R & Curnow A. The cellular and molecular carcinogenic effects of radon exposure: a review. jims. 2013; 14(7): 14024-63.
  6. Jostes R. Genetic, cytogenetic, and carcinogenic effects of radon: a review. MRR. 1996.
  7. Al-Okour A. Radiation Physics: Radiation interaction with matter. Materials Today. Proceedings. 2021; 11.
  8. Peng C, DuPre N, VoPham T, Heng YJ, Baker GM, Rubadue CA, et al. Low dose environmental radon exposure and breast tumor gene expression. BMC cancer. 2020; 20(1): 1-10.
  9. Showard AF, Aswood MS. Measuring of Alpha particles in Blood samples of Leukemia patients in Babylon governorate, Iraq. in Journal of physics. conference series. IOP Publishing. 2019.
  10. Al-Hamzawi AA, Jaafar MS, Tawfiq NF. Uranium concentration in blood samples of Southern Iraqi leukemia patients using CR-39 track detector. JRNC. 2014; 299(3): 1267-72.
  11. Emre et al. Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer, J. Cancer Ther. 2013; 04: 1085–90. DOI: 10.4236/jct.2013.46124.
  12. General Statistical Organization IRAQ. 2021. Available from: https://cosit.gov.iq/ar/63-stat-ar/197-envi-stat.
  13. Fontanetti CS, Nogarol LR, Souza R, Perez DG, Maziviero GT. Bioindicators and biomarkers in the assessment of soil toxicity. Soil contamination. 2011; 1:143-68.
  14. Söğüt Ö, Aydın MF, Küçükönder E , Zorer ÖS , Doğru M. Measurement of gross alpha and gross beta activity concentrations in human tooth. Journal of environmental radioactivity. 2010; 101(3): 226-9.
  15. Kadhim SA, Harjan AH, Alhous SF, AL-Khafaji QS. Study of the difference between uranium concentrations in blood samples of healthy, newly infected and women who took chemotherapy in Iraq, Najaf. in AIP Conference Proceedings. AIP Publishing LLC. 2022.
  16. Obaed HK, Aswood MS. Estimated of U, Rn and Po Concentrations in Smokers Blood Samples Collected from Babylon, Iraq. in IOP Conference Series: Materials Science and Engineering. IOP Publishing. 2020.
  17. Naji TF, Hassoon SO. Measuring of Radon Gas Concentrations in serum samples of Lung cancer patients in Babylon governorate, Iraq. in Journal of Physics: Conference Series. IOP Publishing. 2021.
  18. Mayya YS, Eappen KP, Nambi KS. Methodology for mixed field inhalation dosimetry in monazite areas using a twin-cup dosimeter with three track detectors. Radiation protection Dosimetry. 1998; 77(3):177-7.
  19. Hashim KA, Najam AL, Mohammed JE, Hameed SA. Estimation of Radon Exhalation Rate, Radium Activity and Uranium Concentration in Biscuit Samples in Iraq. IJMP. 2019;16:152-7.
  20. Fleischer RL, Mogro‐Campero A. Mapping of integrated radon emanation for detection of long‐distance migration of gases within the Earth: Techniques and principles. Journal of Geophysical Research: Solid Earth. 1978; 83(B7):3539-10.
  21. Barillon R, Klein D, Chambaudet A, Devillard C. Comparison of effectiveness of three radon detectors (LR115, CR39 and silicon diode pin) placed in a cylindrical device-theory 4):281-2.
  22. Elzain AE. Measurement of Radon-222 concentration levels in water samples in Sudan. Advances in Applied Science Research. 2014; 5(2):229-5.
  23. Azam A, Naqvi AH, Srivastava DS. Radium concentration and radon exhalation measurements using LR-115 type II plastic track detectors. Nuclear geophysics. 1995;6(9):653-4.
  24. Hassan BA, Mohsen AA, Mraity AH, Abojassim AA. Determination of Alpha Particles levels in blood samples of Cancer Patients at Karbala Governorate, Iraq. IJMP. 2019; 16: 41-7.
  25. Salih NF, Sabri MF, Baker AG. Measurement of Radon Concentration in Urine Using PM-355 Detector. in International Conference on Pure and Applied International (ICPAS). 2018.
  26. International Commission on Radiological Protection (ICRP). Radiological protection against radon exposure. ICRP, Stockholm, Sweden. 2018.
  27. Narendran N, Luzhna L, Kovalchuk O. Sex difference of radiation response in occupational and accidental exposure, Front. Genet. 2019;10:1–11, DOI: 10.3389/fgene.2019.00260.
  28. Peired AJ, Riccardo C, Maria L An, Giulia A, Carolina C, Elena L, et al. Sex and Gender Differences in Kidney Cancer: Clinical and Experimental Evidence, Cancers. 2021;13(18):1–

 

 

 

 

 

 

Iranian Journal of Medical Physics
Volume 20, Issue 4
July and August 2023
Pages 194-200

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History

  • Receive Date: 06 April 2022
  • Revise Date: 30 July 2022
  • Accept Date: 10 August 2022

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