Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Random-Forest Model Prediction of Dose Distribution In InsensityModulated Radiation Therapy (IMRT) Planning for Lung Cancer

Document Type : Original Paper

Authors
Ramlah Ramlah 1
Muhammad Fadli 2
Joel Valerian 1
Prawito Prajitno 1
Dwi Seno Kuncoro Sihono 1
1 Department of Physics, Faculty of Mathematics and Natural Sciences, Indonesia University, Depok, 16424, West Java, Indonesia
2 Department of Radiotherapy, MRCCC Siloam Hospital Semanggi, Jakarta, 12930, Indonesia
10.22038/ijmp.2022.64319.2101
Abstract
Introduction: Machine-learning models have been widely used to predict dose distribution in therapy planning such as Intensity Modulated Radiation Therapy (IMRT). Random-forest is one of the machine learning models which can reduce output bias by using the average value all of estimators.
Material and Methods: Planning data in Digital Imaging and Communications in Medicine (DICOM) format is exported to Comma Separated Values (CSV). Then, used to random-forest algorithm that will be trained using 7-fold validation and then the model will be evaluated with new data, i.e., data that the model has never seen before. The data evaluated were the parameters to obtain Homogenety Index (HI) for the target organ, whereas the mean and max dose for organs at risk (OARs) were evaluated. Statistical analysis were also carried out to assess the significant difference between the predicted value and the true value.
Results: Random-forest was able to predict the true value with errors evaluated using Mean Absolute Error (MAE) on Planning Target Volume (PTV) features D2 (0.012), D50 (0.015) and D98 (0.018) as well as at OAR features (Dmean and  Dmax) of the right lung (0.104 and 0.228), left lung (0.094 and 0.27), heart (0.088 and 0.267), spinal cord (0.069 and 0.121) and (V95) Body (0.094). Based on the results of statistical tests, p >0.05, there is no significant difference between the two data.
Conclusion: Random-forest regressor is able to predict the dose value with the smallest difference in PTV features.
Keywords
Radiation Dose Prediction Instensity
Modulated Radiotherapy Machine Learning
Subjects
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Iranian Journal of Medical Physics
Volume 20, Issue 5
September and October 2023
Pages 298-304

  • Receive Date 10 March 2022
  • Revise Date 17 August 2022
  • Accept Date 21 August 2022