Document Type : Original Paper
Authors
1
Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. and Bahar Center for Education, Research and Treatment, Shahroud University of Medical Sciences, Shahroud, Iran.
2
Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
4
Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
6
Associate Professor of Medical Physics, Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Purpose: Radiation therapy in addition to damaging tumor tissue, causes many complications for healthy tissues. Some plant compounds such as cinnamon extract with high antioxidant properties may protect healthy tissues from ionizing radiation. This study aimed to investigate the protective effect of cinnamon on intestinal damage caused by X-rays through histological assessments and biochemical analysis.
Materials and methods: 28 rats were divided into four groups: 1) control, 2) radiation, 3) cinnamon, and 4) cinnamon and radiation. Groups 3 and 4 received the extract by gavage method for 8 days (300 mg/kg twice daily, for 6 days before and 2 days after irradiation), and groups 2 and 4 received 6 Gy whole-body irradiation. 3 days after irradiation, all rats became sacrificed, intestinal and liver tissues were isolated for assessing histopathological changes and biochemical analysis of Malondialdehyde (MDA) and Superoxide dismutase (SOD) respectively.
Results: The results showed that X-ray (6 Gy) increased MDA and decreased SOD in the liver, also increased atrophy, epithelial erosion, inflammation, and goblet cells in the small intestine. Receiving cinnamon extract reduced tissue damages in the small intestine and increased the level of SOD in the liver.
Conclusion: The results showed that the hydroalcoholic extract of the cinnamon plant reduced the effect of radiation on the small intestine, and hence provided radiation protection against X-rays.
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