Radioprotective Effects of Vitis vinifera L. Seed against Radiation-Induced Short-Term Memory Loss in Wistar Rats

Document Type : Original Paper


1 Department of Physics and Engineering Physics, Obafemi Awolowo University, Nigeria

2 Centre for Energy Research and Development, Obafemi Awolowo University, Nigeria

3 Department of Anatomy and Cell Biology, Obafemi Awolowo University, Nigeria




Short-term memory loss is known to progress to cognitive impairment in the individual whose brain is exposed to ionizing radiation. To prevent radiation-induced short-term memory loss, this study investigated the radioprotective effects of Vitis vinifera L. seed against short-term memory loss in Wistar rats

Materials and Methods

Seventy-two young adult male Wistar rats were randomly selected and divided into three equal groups. The rats in Group A were the control group while those in Groups B and C were exposed to a fractionated whole-brain gamma irradiation dose of 40 Gy. In addition, Group C rats were given an oral dose of 100 mg/kg/day of Vitis vinifera L. seed before, during, and after the radiation treatment. Short-term memory and anxiety levels were assessed at weeks 1, 2, 3, and 4 post-radiation. After the assessments, the rats' brains were harvested and processed for routine histology.


The study revealed that group B rats experienced a significant increase in anxiety states, neurodegeneration, and short-term memory loss compared to groups A and C rats (P < 0.005). Group C rats recorded a significant increase in anxiety states compared to Group A. However, there was no significant difference in neurodegeneration except at week 3 (P < 0.005). Also, the memory assessment result became significant at the end of weeks two, three, and four (P < 0.005).


Exposure to 40 Gy of fractionated whole-brain gamma irradiation-induced short-term memory loss in rats. However, Vitis vinifera L. seed attenuated the radiation-induced short-term memory loss.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 31 December 2023
  • Receive Date: 25 October 2023
  • Revise Date: 23 December 2023
  • Accept Date: 31 December 2023