COMPARISON OF METHODS OF µ-MAP GENERATION: MR-BASED METHOD IN PET/MR IMAGING VERSUS PSEUDO-CT METHOD IN RADIOTHERAPY DOSE PLANNING

Articles in Press

Document Type : Original Paper

Authors

1 University of Education,Winneba

2 University of Ghana, School of Nuclear and Allied Health Science

3 University of Ghana, School of Nuclear and Allied Health Science, Federation of African Medical Physics Organizations (FAMPO) and the Ghana Society for Medical Physics (GSMP)

10.22038/ijmp.2024.77457.2369

Abstract

Introduction: This study aimed to compare the similarities and differences in magnetic resonance (MR)-based and pseudo computed tomography (CT) µ-map generation in positron emission tomography/ magnetic resonance (PET/MR) and radiotherapy respectively. In this study options of how attenuation correction could be done on PET hybrid imaging systems and comparison to improve treatment delivery and patient care was explored.

Material and Methods: The methodology involved patient selection, image processing, and generation of both µ-maps for PET-attenuation correction and pseudo-CT for radiotherapy dose planning from computational software packages.

Result: MR-based µ-maps, potentially useful for PET attenuation correction, and pseudo CTs, potentially applicable in radiotherapy planning, were successfully generated. Head images showed MR-based µ-maps overestimating bone for two patients (deviations of 4.0% and 4.2%). Both MR-based and CT µ-maps exhibited dynamic and continuous µ-values for head bone. In the pelvis, pseudo-CT underestimated bone volume in five patients (deviations of 18.7%, 21.3%, 9.6%, 14%, and 10%). Pseudo-CT's bone µ-values lacked continuity compared to CT µ-maps. Pelvis studies revealed more dynamic and broader µ-value range for muscle in CT µ-maps than pseudo-CT and MRI µ-map.

Conclusion: These findings suggest the need for careful consideration and validation of attenuation correction methods, especially in regions with complex anatomical structures, to ensure accurate treatment delivery and enhance patient care in the context of PET/MR and radiotherapy.

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Iranian Journal of Medical Physics

Articles in Press, Accepted Manuscript
Available Online from 12 May 2024

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History

  • Receive Date: 30 January 2024
  • Revise Date: 06 May 2024
  • Accept Date: 12 May 2024

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