Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Integral Dose and Dosimetric Comparison of 3D-CRT, IMRT and VMAT Radiotherapy Techniques for Prostate Cancer

Document Type : Original Paper

Authors
Özlem Mermut 1
Aysun Özsoy Ata 2
Berrin Yalçın 1
Ebru Tuncay 1
Begüm Ökten 1
1 University of Health Sciences Istanbul Training and Research Hospital, Department of Radiation Oncology-İstanbul, Turkey
2 University of Health Sciences Istanbul Training and Research Hospital, Department of Radiation Oncology, Science Private Health Services Medical Physicist
10.22038/ijmp.2025.89332.2575
Abstract
Introduction: This study aimed to compare the treatment planning volumes and the integral doses (ID) during radiotherapy for prostate cancer using three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) techniques.
Material and Methods: The study included 10 patients treated in our clinic, diagnosed with intermediate risk prostate cancer at the T2bN0M0 stage, Gleason score ≤ 7 and prostate-specific antigen (PSA) levels between 10-20 ng/mL. For each patient, 6 MV photon energy was used for 3D-CRT, IMRT and VMAT planning.
Results: The rectum, bladder, right and left femur, body IDs, the homogeneity index (HI), and conformity index (CI) values were found to be higher in 3D-CRT planning compared to IMRT and VMAT planning (p < 0.001). The body mean, and ID were lower in VMAT planning compared to IMRT and 3D-CRT plans (p < 0.001). The monitor unit (MU) value was significantly higher in the IMRT planning compared to VMAT and 3D-CRT plans, and higher in the VMAT plan compared to 3D-CRT plans (p < 0.001).
Conclusion: According to our study, for organ protection, body ID doses and HI, as well as CI, the VMAT planning technique is mostly superior to IMRT and 3D-CRT. In terms of MU, the 3D-CRT planning technique is better than the others. Our findings indicate that VMAT could generate plans that deliver lower IDs to healthy tissues while providing relatively uniform doses to the target area; and lower MUs.
Keywords
Integral dose
Dosimetric Comparison
Prostate Cancer
Subjects
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Iranian Journal of Medical Physics
Volume 22, Issue 6 - Serial Number 6
November and December 2025
Pages 405-410

  • Receive Date 09 July 2025
  • Revise Date 21 September 2025
  • Accept Date 25 November 2025