Calculation of the Dose of Samarium-153-Ethylene Diamine Tetramethylene Phosphonate (153Sm-EDTMP) as a Radiopharmaceutical for Pain Relief of bone Metastasis

Razghandi, Fatemeh; Izadi, Reza; Mowlavi, Ali

doi:10.22038/ijmp.2016.6843

Calculation of the Dose of Samarium-153-Ethylene Diamine Tetramethylene Phosphonate (153Sm-EDTMP) as a Radiopharmaceutical for Pain Relief of bone Metastasis

Document Type : Original Paper

Authors

Fatemeh Razghandi ¹

Reza Izadi ¹

Ali Mowlavi ²

¹ Department of Physics, School of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

² Department of Physics, Hakim Sabzevari University, Sabzevar, Iran International Centre for Theoretical Physics, Associate and Federation Schemes, Medical Physics Field, Trieste, Italy

10.22038/ijmp.2016.6843

Abstract

Introduction
One of the important applications of nuclear physics in medicine is the use of radioactive elements as radiopharmaceuticals. Metastatic bone disease is the most common form of malignant bone tumors. Samarium-153-ethylene diamine tetramethylene phosphonate (¹⁵³Sm-EDTMP) as a radiopharmaceutical is used for pain palliation. This radiopharmaceutical usually emits beta particles, which have a high uptake in bone tissues. The purpose of this study was to calculate the radiation dose distribution of ¹⁵³Sm-EDTMP in bone and other tissues, using MCNPX Monte Carlo code in the particle transport model.
Materials and Methods
Dose delivery to the bone was simulated by seeking radiopharmaceuticals on the bone surface. The phantom model had a simple cylindrical geometry and included bone, bone marrow, and soft tissue.
Results
The simulation results showed that a significant amount of radiation dose was delivered to the bone by the use of this radiopharmaceutical.
Conclusion
Thebone acted as a fine protective shield against rays for the bone marrow. Therefore, the trivial absorbed dose by the bone marrow caused less damage to bone-making cells. Also, the high absorbed dose of the bone could destroy cancer cells and relieve the pain in the bone.

Keywords

Dose Distribution

MCNPX Code

153Sm-EDTMP

Subjects