The Experimental Study of Increased ICP on Cerebral Hemorrhage Rabbits with Magnetic Induction Phase Shift Method

Document Type : Original Paper


1 Department of Neurosurgery, Southwest Hospital, Third Military Medical University, No.29 Gaotanyanzheng Street, Shapingba District, Chongqing 400038, China

2 College of Biomedical Engineering, Third Military Medical University, No. 30 Gaotanyanzheng Street, Shapingba District, Chongqing 400038, China

3 College of Bioengineering, Chongqing University, No. 174 Shazheng Street, Shapingba District, Chongqing40044, China


Measuring magnetic induction phase shift (MIPS) changes as a function of cerebral hemorrhage volume has the potential for being a simple method for primary and non-contact detection of the occurrence and progress of cerebral hemorrhage. Our previous MIPS study showed that the intracranial pressure (ICP) was used as a contrast index and found the primary correlation between MIPS and ICP.
Materials and Methods
In this study,we theoretically deduced the approximate relationship between MIPS and ICP and carried out a comparison study between MIPS and ICP on cerebral hemorrhage in rabbits in this study. Acute cerebral hemorrhage was induced by injecting autologous blood (3 to 6mL) into the brain of rabbits in the experimental group (n=7).
The animal experiment results showed that the MIPS decreased significantly as a function of injection volume in the experimental group and the changes of ICP and MIPS of rabbits from experimental group presented a negative correlation. We also found that the MIPS slopes of all experimental samples had a change trend from fastness to slowness with a reverse of the change of ICP.
These observations suggested that the non-contact MIPS method might be valuable and potential for monitoring acute cerebral hemorrhage and obtaining the ICP information.


Main Subjects