Introduction: The medical applications of ultrasound on human brain are highly limited by the phase and amplitude aberrations induced by the heterogeneities of the skull. However, it has been shown that time reversing coupled with amplitude compensation can overcome these aberrations. In this work, a model for 2D simulation of the time reversal mirror technique is proposed to study the possibility of targeting any point within the brain without the need for craniotomy and to calculate the acoustic pressure field and the resulting temperature distribution within the skull and brain during a High Intensity Focused Ultrasound (HIFU) transcranial therapy.
Materials and Methods: To overcome the sensitivity of the wave pattern to the heterogeneous geometry of the skull, a real MRI derived 2D model is constructed. The model should include the real geometry of brain and skull. The model should also include the couplant medium which has the responsibility of coupling the transducer to the skull for the penetration of ultrasound. The clinical substance used as the couplant is water. The acoustic and thermal parameters are derived from the references. Next, the wave propagation through the skull is computed based on the Helmholtz equation, with a 2D finite element analysis. The acoustic simulation is combined with a 2D thermal diffusion analysis based on Pennes Bioheat equation and the temperature elevation inside the skull and brain is computed. The numerical simulations were performed using the FEMLAB 3.2 software on a PC having 8 GB RAM and a 2.4 MHz dual CPU.
Results: It is seen that the ultrasonic waves are exactly focalized at the location where the hydrophone has been previously implanted. There is no penetration into the sinuses and the waves are reflected from their surface because of the high discrepancy between the speed of sound in bone and air.  Under the focal pressure of 2.5 MPa and after 4 seconds of sonication the temperature at the focus reached 51 °C and the temperature of the pre-target bone increased to 56.31 °C. In the post-target region the temperature of the sphenoid bone increased to 47.1 °C while the temperature of the occipital bones reached up to 46 °C. It is also shown that by using a cold water cooling system and cooling down the pre-target bones to 20 °C before sonication, the maximum pre-target bone temperature will not exceed 40 °C and hence the pre-target bone cells will remain intact.
Discussion and Conclusion: In this study, it is well demonstrated that by using the time reversal mirror technique it is possible to target any point within the skull without the need for craniotomy. Although at higher acoustic frequencies compared to the lower ones such as 300 kHz the ultrasound undergoes more severe aberrations while passing through media having geometrical heterogeneity and discrepant sound velocities, the simulations performed in this work show that even at such frequencies it is still possible to correct these aberrations using the time reversal mirror technique. The thermal simulations show that by using this method the temperature of the deep seated tumors can be increased to cytotoxic temperature in a few seconds.