Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Calculation the accumulated dose in the heart and its effect on other human organs by using experimental mouse data and the MCNPX code for FDG

Document Type : Conference Proceedings

Authors
Mehrnaz Rahmanpour 1
Asghar Haddadi 1
Fatemeh Bolorinovin 2
Mitra Athari 1
1 Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 Atomic Energy Organization of Iran, Nuclear Science and Tecnology Research Institute, Alborz Research institutr, Karaj-Iran
10.22038/ijmp.2018.11853
Abstract
Introduction: The use of ionizing radiation in diagnostic medicine is expanding, and considering the fact that the practical dosimeter in a precise way is almost impossible, the Monte Carlo computational methods help researchers, to have coming up the lowest cost and error of the distribution of doses in the patient's body.
 
Materials and Methods: In this study, after infusion of 7 to 8 MBq of FDG radioisotope to rat, and the maturation of the body of the mouse, the rate of accumulation of this radioactive drug in various organs of the rat body was measured using the HPGe detector and its activity was calculated and generalized to human. the accumulation dose of heart effecting on other organs was calculated by using MCNPX code, assuming that the injectable drug to humans was 185 MBq, was calculated.
 
Results: accumulation dose of heart effecting on other organs was calculated by using MCNPX code; that the result of calculation reveals that the highest received dose from the heart to the organs, respectively is related to the heart, lung, liver, stomach, rib cage, spleen, kidney, large intestine brain.
 
Conclusion: Finally, using the MIRD phantom in the MCNPX2.6 computational code, the heart organs in this simulation were determined as the source and the dose rate received by other organs was calculated.
Keywords
Dose FDG
Heart MIRD

  • Receive Date 21 May 2018
  • Revise Date 28 November 2018
  • Accept Date 06 July 2018