Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Automatic Segmentation of the Gross Tumor Volume in Prostate Carcinoma Using Fuzzy Clustering in Gallium-68 PSMA PET/CT Scan

Document Type : Conference Proceedings

Authors
Khadijeh Bamneshin 1
Ahmad Bitarafan rajabi 2
Seied Rabi Mahdavi 3
Parham Geramifar 4
1 Iran University of Medical Science, Tehran, Iran
2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR
3 Medical Physics Department, Tehran University of Medical Science, Tehran, Iran
4 Asisstant Professor, Tehran University of Medical Sciences, Tehran, Iran
10.22038/ijmp.2018.11880
Abstract
Introduction: Modern radiotherapy (RT) techniques allow a highly precise deposition of the radiation dose in tumor. So, high conformal tumor doses can be reached while sparing critical organs at risk.
Materials and Methods: This study was conducted in three phases. In the first phase; Fourteen patients with primary or recurrent prostate cancer receive Gallium-68 PSMA PET/CT planned 3D conformal or intensity modulated radio therapy. In the second phase; fuzzy clustering method to definition the gross volume tumor in prostate. In the next phase; increasing the dose in the tumor according to the functional and molecular information assessed by combined PET/CT imaging and result of clustering.
Result: The mean standard uptake value (Suv) was 6.2 in the lesion of the prostate. To administer 75.6Gy to the entire prostate with a boost dose to 84Gy, was feasible.
Conclusion: The additional of the simultaneous integrated boost(SIB) was associated with greater control but not toxicity.
Keywords
Radiotherapy
Gallium-68
PET/CT

  • Receive Date 21 May 2018
  • Revise Date 01 December 2018
  • Accept Date 06 July 2018