Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Effective dose assessment in body organs after injection of 131I-MIBG

Document Type : Conference Proceedings

Authors
Elham mirmosayeb 1
Mehdi Salehi Barough 1
Seyed Pezhman Shirmardi 2
1 Department of Nuclear Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.
10.22038/ijmp.2018.13130
Abstract
Introduction:
Development of a novel radiopharmaceutical needs assessment of its biological- distribution in animal models, most commonly mice prior to its common application.
This study describes the biodistribution and absorbed dose prediction 131I-MIBG in human organs after injection in mice.
 
Materials and Methods:
In this research, 131I-MIBG radiopharmaceutical was injected to mice. After 4, 12, 24, and 48 hours post injection, the mice sacrificed and its organs dissected and counted by well detector. Then with having the Injected dose per gram of organs, absorbed dose of organs was calculated by MCNP simulation code and MIRD methods.
 
Results:
The results showed that the intestine and thyroid organs absorbed the least and most dose after injection of 131I-MIBG in mice.
 
Conclusion:
Many studies have demonstrated the usefulness of using animal distribution as a model for absorbed dose estimations in humans. Radiation dosimetry for 131I-MIBG was estimated for humans based on the biodistribution data in normal mice. The obtained results by MIRD and MCNP had shown close results.
Keywords
radiopharmaceutical
131I-MIBG
Dosimetry

  • Receive Date 21 May 2018
  • Revise Date 19 May 2019
  • Accept Date 06 July 2018