Iranian Journal of Medical Physics

Iranian Journal of Medical Physics

Evaluation of the Effects of Curcumin and Lycopene Treatment on Human Lymphocytes before 2 and 6 Gy of 6 MV X-Ray Irradiation

Document Type : Original Paper

Authors
Reza Fardid 1
Hossein Fazilatpour 2
Narges Ebrahimi 2
Ali Sadeghi 2
Tahereh Zare 3
1 Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2 Student Research Committee, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
10.22038/ijmp.2020.44248.1676
Abstract
Introduction: Today, the use of ionizing radiation in medicine has grown as an important tool for diagnosis and treatment of diseases. However, the harmful effects of radiation should be also considered. Some substances such as lycopene and curcumin can reduce or increase the harmful effects of radiation on humans. So the aim of this study was to evaluate the radioprotective effects of lycopene and curcumin based on the MN assay.
Material and Methods: In this study, the effects of lycopene and curcumin on reducing or increasing the harmful effects of radiation were studied using the micronucleus assay. The effects of lycopene (5 μg/mL) and curcumin (5 μg/mL) were evaluated at radiation doses of 2 and 6 Gy.
Results: The results indicated that the simultaneous use of curcumin and lycopene can be radioprotective at low radiation doses (2 Gy; p <0.001) and radiosensitizing at high doses (6 Gy; P>0.05).
Conclusion: Based on the present results, further research using other methods may contribute to our understanding of the effect of simultaneous use of curcumin and lycopene at low and high doses of X-ray radiation.
Keywords
Lycopene
Curcumin
Radiation
Micronucleus Assay
Subjects
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Iranian Journal of Medical Physics
Volume 18, Issue 2
March and April 2021
Pages 117-122

  • Receive Date 06 November 2019
  • Revise Date 10 January 2020
  • Accept Date 18 May 2020